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Qu'est-ce (qui) est running repair - définition
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![Maximum human speed [km/h] and pace [min/km] per distance](https://commons.wikimedia.org/wiki/Special:FilePath/Human speed distance portrait.png?width=200 "Maximum human speed [km/h] and pace [min/km] per distance")
![A scene depicting long-distance runners, originally found on a [[Panathenaic amphora]] from Ancient Greece, circa 333 BCE](https://commons.wikimedia.org/wiki/Special:FilePath/Long Distance Runners, Ancient Greece, Amphora.png?width=200 "A scene depicting long-distance runners, originally found on a [[Panathenaic amphora]] from Ancient Greece, circa 333 BCE")
![[[Eadweard Muybridge]] photo sequence](https://commons.wikimedia.org/wiki/Special:FilePath/Muybridge runner.jpg?width=200 "[[Eadweard Muybridge]] photo sequence")
![Roman bronze sculptures]] of runners from the [[Villa of the Papyri]] at [[Herculaneum]], now in the [[Naples National Archaeological Museum]]](https://commons.wikimedia.org/wiki/Special:FilePath/Runners MAN Napoli Inv5626-7 n02.jpg?width=200 "Roman bronze sculptures]] of runners from the [[Villa of the Papyri]] at [[Herculaneum]], now in the [[Naples National Archaeological Museum]]")
![International-level women athletes competing in 100 m sprint race at [[ISTAF Berlin]], 2006](https://commons.wikimedia.org/wiki/Special:FilePath/Sina Schielke (192) wins the 100 metres race - ISTAF 2006 - Berlin, 3 September.jpg?width=200 "International-level women athletes competing in 100 m sprint race at [[ISTAF Berlin]], 2006")
Wikipédia
Nucleotide excision repair is a DNA repair mechanism. DNA damage occurs constantly because of chemicals (e.g. intercalating agents), radiation and other mutagens. Three excision repair pathways exist to repair single stranded DNA damage: Nucleotide excision repair (NER), base excision repair (BER), and DNA mismatch repair (MMR). While the BER pathway can recognize specific non-bulky lesions in DNA, it can correct only damaged bases that are removed by specific glycosylases. Similarly, the MMR pathway only targets mismatched Watson-Crick base pairs.
Nucleotide excision repair (NER) is a particularly important excision mechanism that removes DNA damage induced by ultraviolet light (UV). UV DNA damage results in bulky DNA adducts - these adducts are mostly thymine dimers and 6,4-photoproducts. Recognition of the damage leads to removal of a short single-stranded DNA segment that contains the lesion. The undamaged single-stranded DNA remains and DNA polymerase uses it as a template to synthesize a short complementary sequence. Final ligation to complete NER and form a double stranded DNA is carried out by DNA ligase. NER can be divided into two subpathways: global genomic NER (GG-NER or GGR) and transcription coupled NER (TC-NER or TCR). The two subpathways differ in how they recognize DNA damage but they share the same process for lesion incision, repair, and ligation.
The importance of NER is evidenced by the severe human diseases that result from in-born genetic mutations of NER proteins. Xeroderma pigmentosum and Cockayne's syndrome are two examples of NER associated diseases.
